According to an article by Charles Q. Choi in the August 2009 issue of Scientific American magazine, the plant Water Celery(Oenanthe crocata) contains a toxin that forces a human's facial muscles to contract into a rictus. A potion using this plan was used in ancient Sardinia by Phoenician colonists to put a smile on the face of people condemned to
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I can't decide whether this counts as life immitating art or art immitating life. Depends on whether the Joker's creators knew, I guess.
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So, historical AU Joker?
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