Faceache doesn't support cut-tags, so I'm placing my prediction here on LJ under the cut.
The Doctor that got shot in episode 1 was a "Ganger". "Gangers" are clones that appeared in episodes 5-6 Rebel Flesh / Almost People. In episodes 5-6 a Ganger Doctor has already been shown, but he sacrificed himself to save the others. I predict that the shot Doctor will turn out to be a second Ganger clone.
Also, the Eye Patch Lady is a future incarnation of Melody Pond / River Song.