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Author L Rea responded to a message on rxmuscle.com with some great comments about the ergogenic benefits of malic acid, which is esterified (or otherwise chemically bonded with), with branched chain amino acids in the ALRI supplement "Chaind Out". Author is the CEO of ALR Industries (ALRI
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The science sounds plausible, although I'd want to see the references to make sure that he's not making stuff up.
Even then, I'm still suspicious that his supplement will necessarily do what it claims. There are people doing this kind of research, but there are also people who are trying to disguise themselves as research to make a buck. I'm not sure how to check. Possibly see whether there's any clinical trial or publication data for it's use treating FM. If it's being (or is intended to be) put into sale as a pharmaceutical (and it certainly could be if it's been modified to make it less resistant to breakdown), it has to prove that it's effective. If it's just being sold as a supplement - even if it makes the clear claim that it can treat a medical condition - it doesn't have to prove anything.
Caveat emptor.
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One, "Systemic drug treatment for chronic musculoskeletal pain" (2001), is a review article that includes malic acid among those for which there was evidence of no effectiveness for managing the chronic pain of FM.
The other, "Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study" (1995), found effectiveness after the end of the trial and with a higher dose than allotted by the protocol. "Super Malic" is a "proprietary tablet" so that makes the study a little suspicious.
I agree with you, Dave. It is very hard to know what to believe about supplements.
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