Persona 4
Yes this game has a lot of serious moments with a serious plot line but my god... the humour in this one was very good. There is a good mix of great jokes and great plot in this game. As much as I liked Three, it started out with the jokes but man did it turn serious business. Even after the FOOLED YOU senario in Persona 4, they still managed to keep it funny.
Also I think I died a little when you first see Kanji’s ‘other’ self. I think I dropped a lung laughing.
Also:
Cho Aniki for the PS1
For obvious reasons. XD