It's = it is; "It's 9:25 PM"
Its = possessive of 'it'; "The dog wagged its tail."
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There = describes a place; "Go sit over there, please."
Their = possessive of 'they'; "That's their house."
They're = they are; "They're not home."
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Your = possessive of 'you'; "Please wash your hands before dinner."
You're = you are; "You're annoying
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