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It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis.
Since PDE5 inhibitors such as Cialis may cause transiently low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of Cialis.
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In the United States, Cialis has Food and Drug Administration approval and became available in December, 2003 as the third pill after Viagra and Levitra. Due to its 36-hour effect it is also known as the "Weekend Pill".
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