Season Five Spoilers
Season 5 starts out with all the "kids" in different parts of the country. Brooke is in NYC for "Clothes over Bros".. Peyton is in LA working for a record company.. Haley and Nathan are in Tree Hill as Haley teaches at Tree Hill High School. Haley and Nathan are looking to hire a nanny. Haley has trouble finding the right one, Peyton and Brooke help out. It is rumoured that "Karen's Cafe" is no longer there and will not be part of the story line anymore. More to come..
from http://onetreehillfans.com/spoilers/