Blue Marble
Here's Earth from Apollo 17 en route to the Moon. That's everything we have. Every single human being that has ever lived and died did it there. Earth weighs about 6,000,000,000,000,000,000,000,000 kg, you weigh about 70 kg. Compared to Earth, we're all insignificant.
Pale Blue Dot
Here's Earth again, this time photographed by Voyager 1 from 6,000,000,000 km away as it left the Solar System. That "pale blue dot" you see circled there is us, sitting in a line of lens flare. According to NASA, from that distance the planet covered barely more than 10% of a single pixel. Compared to the size of the Solar System, Earth is insignificant.
M104 / The Sombrero Galaxy
Here's the Sombrero Galaxy, it's the same type as our own Milky Way Galaxy. Including our sun, there are between 200 and 400 billion of stars in our galaxy. Each one of those stars is likely in a system with other stars and planets, and a very small percentage of these systems probably have planets similar to Earth. Compared to a galaxy, the Solar System is insignificant.
Hubble Ultra Deep Field
Here is a photo of what normally appears to be an empty area of space. Combining 800 exposures by the Hubble Telescope of the same spot into a single image, however, revealed that it's anything but empty. What was photographed is simply an area where there are few stars between Earth and the edge of our galaxy; like a window looking out into the Universe. Though a handful of nearby stars made it into the photo, nearly all of the 10,000 or so glowing dots and swirls is a galaxy, each one containing billions or even trillions of stars. Despite the impressive number of visible galaxies, the photographed area is only the size of your pinky nail at arms length, covering just 1 / 13,000,000 of the entire sky.
Compared to the Universe, we are all absolutely, utterly insignificant. How cool is that?