Most mail programs open up attachments by saving them to the Windows temporary directory, then passing the file to the appropriate program; when the program to display the attachment exits, the mail client may or may not delete the temporary file, but if you click on the attachment again, the client will save a fresh copy of the attachment into the temporary directory. The only way to be sure of saving your changes for later is to either save the attachment to disk, then modify the saved file, or to open the attachment, modify it, then use 'Save As' to save the modified file somewhere other than the temporary directory. Either way, you're making a permanent copy of the file, instead of using temporary copies.
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